The Immuno-Mass Spectrometry Chemical Microscope

DJ Hare; O Shimoni; DP Bishop

Journal article

The Immuno-Mass Spectrometry Chemical Microscope

DJ Hare, O Shimoni, DP Bishop

Trends in Chemistry | CELL PRESS | Published : 2020

DOI: 10.1016/j.trechm.2020.02.014

Abstract

Elemental mass spectrometry (MS) imaging has evolved beyond mapping biometals in tissue sections. The continually improving sensitivity and spatial resolution of chemical imaging technology has the potential to revolutionize immunohistochemistry (IHC). We explore how simple modifications to routine immunostaining protocols that integrate ‘immuno-MS imaging’ (iMSI) are making in situ quantitative protein mapping a reality.

University of Melbourne Researchers

Dominic Hare Author

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Grants

Awarded by Agilent Technologies

Funding Acknowledgements

D.J.H. is supported by a research fellowship from the National Health and Medical Research Council (GNT1122981). O.S. is supported by the Australian Research Council Industrial Training Center (IH150100028) and acknowledges the Australian Research Council and the National Health and Medical Research Council for financial support (GNT1101258). D.P.B. is supported by an Australian Research Council Discovery Early Career Researcher Award (DE180100194) and a National Institute of Health R21 Exploratory/Development Grant (R21AR072950).